Using electrical mapping technology, ventricular tachycardia was induced and recorded in vivo. The results showed that under the same stimulation conditions, the hearts of wild-type pigs were successfully paced and immediately reverted to normal sinus rhythm after stimulation ceased.

In contrast, gene-mutated pigs exhibited severe ventricular fibrillation. After stimulation stopped, the conduction maps revealed multiple wave breaks, indicating increased ventricular repolarization heterogeneity and a higher susceptibility to malignant arrhythmias.

Left panel) displays electrocardiograms recorded under anesthesia in wild-type and gene-mutated pigs during burst pacing (S1S1) induction, with the gene-mutated pigs developing sustained ventricular fibrillation. The right panel presents conduction maps, illustrating the cardiac conduction characteristics during baseline sinus rhythm before stimulation, sinus rhythm in wild-type pigs after stimulation, and arrhythmias in gene-mutated pigs after stimulation.

Circulation ( IF  38.6)   

https:/do0rg/10.1161/CIRCULATIONAHA125.074681