Schematic Diagram of the Optical Path
Optical Path
Optical Mapping System and
Supporting Equipment
Dye Loading in the Ex Vivo Whole Heart
Simultaneous Acquisition of Action Potential (AP) and Calcium Transient (CaT) Signals From Tens of Thousands of Channels
Action Potentials and Intracellular Calcium Signals
Measurable parameters: action potential activation rate; pacemaker site localization; conduction time; conduction direction; conduction velocity; conduction heterogeneity; depolarization duration; action potential duration (APD10–90); APD10–90 heterogeneity; electrical alternans amplitude mapping; calcium transient conduction direction; calcium transient duration; electrocardiogram (ECG); coronary perfusion pressure; myocardial contractile force (tension); perfusion temperature.
Sinus Rhythm
Stimulator @6Hz
Active Time
Conduct Video
Calcium Signals
Action Potentials
【Advanced Materials】Pericardial Delivery of SDF-1 a Puerarin Hydrogel Promotes Heart Repair and Electrical Coupling
The contraction and relaxation of cardiomyocytes rely on periodic action potentials, a process closely associated with calcium. Impaired myocardial function is partly attributed to alterations in excitation ...
【Exploration】Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling
Using optical mapping to analyze action potentials in different regions of the heart (normal zone (N), peri-infarct zone (P), and infarct zone (I) of the myocardial infarction heart), it was found that comp ...
【Nature Communications】Engineered model of heart tissue repair for exploring fibrotic processes and therapeutic interventions
MI frequently precipitates arrhythmias by impairing CM function and inducing fibrosis, which impedes cardiac electrical signal propagation. Utilizing cardiac optical mapping with calcium-sensitive dye, they ...
【Advanced science】P21-Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy
Using optical mapping, electrophysiological changes were compared between Langendorff-perfused Pak2cko and Pak2f/f hearts. Under baseline conditions, there was no difference in the incidence of ventricular ...
【Cardiovascular research】Coupling of USP10 de-ubiquitination and chaperone-mediated autophagy causes cardiac sodium channel degradation and cardiac arrhythmias
Optical mapping confirmed prolonged activation time and reduced conduction velocity in both sinus rhythm and pacing modes. Programmed electrical stimulation experiments demonstrated a high incidence of indu ...
【Theranostics】Brain‑to‑heart cholinergic synapse‑calcium signaling mediates ischemic stroke‑induced atrial fibrillation
In this study, an atrial fibrillation rat model induced by ischemic stroke was established. Optical mapping technology was employed to detect action potentials and calcium transient signals in different mod ...
【Journal of Ethnopharmacology】Traditional Chinese Medicine YangxinDingji alleviates arrhythmias through inhibition of sodium and L-type calcium channels
Using optical mapping technology on isolated hearts, this study investigated the effects of Yangxin Dingji Capsule on electrical and calcium disturbances in heart models stimulated by isoproterenol (ISO). I ...
【Cardiovascular research】Senescent CD8+ T cells: a novel risk factor in atrial fibrillation
To further clarify the potential role of IFN-γ in susceptibility to atrial fibrillation, the researchers performed optical mapping on rat hearts. Although IFN-γ perfusion did not significantly alter the atr ...
