The Electrical Mapping Systems (EMS) are equipped with the new generation of Multi-Electrode Arrays (MEAs) and high-performance amplifiers. The advanced EMapping software facilitates fast recordings of field potentials from in vitro, in vivo, and ex vivo cardiac samples. The electrical activities and conductive information can be studied in great details at tissue level. The precision of data acquisition system makes it possible to accurately detect abnormalities on ion channels. It also can be grouped with other devices such as ventricular or coronary pressure probe, monophasic action potential system (MAP), myocardial tension, perfusion temperature and the optical mapping system. These features immensely empower cardiac electrophysiological researchers to understand better about mechanisms of cardiac arrhythmias. Our system is also an ideal candidate for efficiently screening new anti-arrhythmic drugs and testing drug toxicity.