Cui et al. (2024) reveal that LncRNA-CIR6 facilitates the differentiation of mesenchymal stem cells into cardiogenic cells, improves cardiac function, and reduces myocardial infarction and fibrosis, highlighting the critical role of CDK1 in this process. Additionally, the study utilized a multi-electrode array electrical mapping system (32 channels), which effectively evaluated left ventricular conduction and epicardial electrical activation in a whole heart Langendorff setup.

For more information, visit https://pubmed.ncbi.nlm.nih.gov/38542439/

#cardiotwitter #opticalmapping #Cardiology #Langendorff #calcium #heart #electrophysiology #Regeneration #ElectricalMapping #arrhythmia #science

Huang et al. (2024) demonstrate that microtubule depolymerization, driven by the activation of the P38MAPK signaling pathway, is a key mechanism underlying the downregulation of Cx43 in ICDs following myocardial I/R. In this study, the electrical mapping system (with 64-channel MEA) was featured and used in a Langendorff heart setup to assess left ventricular conduction and epicardial activation, making it an ideal approach for investigating cardiac function.

For more information, visit https://pubmed.ncbi.nlm.nih.gov/38696081/