Cao et. al. (2022) found prolonged infusion of high dosages of esketamine altered the cardiac electrophysiological effects and caused visible conduction heterogeneities. This could be important for cardiac safety as esketamine is favored in clinical settings. The electrical mapping system with a multi-electrode array (8×8 grid) was used to record epicardial field potential of the left ventricle. Isochronal maps and conduction velocity were then generated by EMapScope software. Besides, the optical mapping system was used to measure calcium transient and membrane potential, as important parameters in cardiac electrophysiology.
Liu et. al. (2022) showed that knockdown of MAPK10 attenuated diabetes mellitus (DM)-induced atrial fibrillation (AF) by reducing structural remodeling and electrical remodeling through inhibition of inflammation, fibrosis, electrical disorder and apoptosis. This suggests that targeting MAPK10 may represent a potential therapeutic approach to treat DM-induced AF. The optical mapping system was used to measure transmembrane potential. Activation maps, APD, conduction velocity were further computed by OMapScope software.