Using electrical and optical mapping, the negative chronotropic effect of SR was determined in langendorff-perfused rat or guinea-pig hearts. The antiarrhythmic activity of SR was assessed by the ex vivo tachyarrhythmia models induced by left coronary artery ligation (LCAL) and isoproterenol (ISO). Canonical models of aconitine and ouabain-induced arrhythmia were used to verify the antiarrhythmic effects in vivo.

A: Recording configuration. B: Representative voltage RH237 optical mapping recording of active time. C: Representative voltage RH237 optical mapping recording of APD90. D: Summary results of mean activation time and conduction velocity and APD90. n = 7 isolated hearts of guinea pigs.

Phytomedicine (IF 8.3) Song T, Hao Y, Wang M, et. Sophoridine manifests as a leading compound for anti-arrhythmia with multiple ion-channel blocking effects. Phytomedicine. 2023 Apr;112:154688. doi: 10.1016/j.phymed.2023.154688. Epub 2023 Jan 31. PMID: 36738478.