Confirmed by electrical mapping technology, the CNP/Sema3A-loaded hydrogel can significantly increase the electrical impulse conduction velocity of infarcted myocardial tissue and reduce conduction dispersion, and this effect may be associated with changes in the composition of infarcted tissue. In addition, animals treated with the CNP/Sema3A-loaded hydrogel exhibit a shorter QRS interval, a phenomenon that is particularly prominent at 7 days after myocardial infarction (MI), suggesting that the cardiac electrical conduction function in this treatment group is better preserved.

direction (F) and ECG dispersion (H). Calculate the conduction velocity (G) and dispersion velocity (I). Electrocardiogram (J) was recorded and QRS interval (K) was measured. Data are shown as mean ± S.D. One-way analysis of variance (ANOVA) was applied for statistical analysis.

Composite Part B: Engerring (IF 12.7)

https://doi.org/10.1016/j.compositesb.2025.112300