Previous studies suggested that conductive CPs could act as a robust tool to improve the electrical integration in the infarcted hearts, which was essential for the MI repair. Here, they directly evaluated the influence of different CPs on electrical integration by measuring the electrical conduction velocities and local potential amplitudes between healthy and infarcted cardiac tissues within isolated Langendorff-perfused hearts after surgery for 28 days using an electrical mapping system.

SP hydrogel ECP promoted electrical conduction and revascularization in the infarcted heart.

(A) Representative electrical maps of the isolated rat heart in different ECP groups. The earliest activation is exhibited in red, the latest activation is shown in blue, and the numbers indicate the activation time (ms).

(B) The CV between infarcted and healthy sites is significantly improved in the SP hydrogel ECP groups.

Bioactive Materials (IF20.3)

https://doi.org/10.1016/j.bioactmat.2024.02.012