To elucidate the electrophysiological mechanism of YXDJ, optical mapping was used to assess its impact on cardiac electrical and calcium disturbances in the isolated hearts.

(A) The schematic diagram for experimental procedures in the different groups. (B) Optical AP traces and activation maps after I/R. Arrows indicate the direction of conduction. (C) Typical action potential duration (APD) dispersion map and corresponding summary results of APD dispersion after reperfusion. (D) Typical AP conduction map and corresponding summary data for inhomogeneity of AP conduction after reperfusion. (E) Optical CaTs traces and activation maps after reperfusion.

Journal of ethnopharmacology (IF 5.4)

Qiu, S., Sun, J., Su, S., Wu, W., Zhang, J., Qi, J., & Xu, Y. (2025). Traditional Chinese Medicine YangxinDingji alleviates arrhythmias through inhibition of sodium and L-type calcium channels. Journal of ethnopharmacology, 347, 119803. https://doi.org/10.1016/j.jep.2025.119803