The effects of exenatide on cardiac electrophysiology and atrial fibrillation (AF) activity were investigated in isolated rat hearts using an electrical mapping system. Its antiarrhythmic potential was subsequently evaluated in a rat model of AF induced by acetylcholine and calcium chloride.

(F ) Illustration showing mapping electrode array placement on the sinus node. (G) High-density maps of activation times were measured across the array (n = 4). Representative maps at baseline (left) and after GLP-1 superfusion (right) are shown. Note the shift in site of earliest activation towards the crista terminalis. (H) Representative high-resolution maps of activation times measured at baseline (left) and in the presence of ivabradine (middle) and ivabradine + GLP-1 (right).

The Journal of biological chemistry (IF 3.9)

Zhou Q, Hao G, Xie W, et al. Exenatide reduces atrial fibrillation susceptibility by inhibiting hKv1.5 and hNav1.5 channels. J Biol Chem. 2024;300(5):107294. doi:10.1016/j.jbc.2024.107294