The Sanwei Tanxiang decoction powder slowed the heart rate and conduction velocity in normal rats; significantly prolonged ventricular repolarization time and effective refractory period, and mildly extended atrioventricular delay time. Based on the findings from electrical mapping, a series of patch-clamp experiments were subsequently conducted.

A. Schematic diagram of cardiac mapping. B. Experimental process diagram of the control group and SWTX intervention group. C. After preincubation and administration, field electricity in normal and myocardial infarction areas in the myocardial infarction treatment and myocardial infarction groups after 6 Hz stimulation. D. After ischemia–reperfusion, 50 Hz stimulation induced ventricular fibrillation in the SWTX intervention and control groups. Ventricular fibrillations appeared less frequently in the SWTX intervention group, and early and late depolarizations were suppressed. E. After ischemia–reperfusion, the probability of ventricular fibrillation induced by 50 Hz stimulation in the SWTX intervention and control groups. The probability of ventricular fibrillation was significantly reduced after SWTX treatment. F. After preincubation and administration, the field potential after 6 Hz stimulation at the apex of the normal and myocardial infarction areas in the myocardial infarction treatment and myocardial infarction groups.

Biomedicine & pharmacotherapy (IF 7.5)

DOI:10.1016/j.biopha.2022.114103