Schematic Diagram of the Optical Path
Optical Path
Optical Mapping System and Accessories
Dye loading of the heart
Simultaneous Acquisition of AP and Ca Transient
From Tens of Thousands of Channels
【ACS Pharmacol Transl Sci】Electrophysiological and Proarrhythmic Effects of Hydroxychloroquine Challenge in Guinea-Pig Hearts
Effects of μM-HCQ were studied in isolated perfused guinea-pig hearts by multielectrode, optical RH237 voltage, and Rhod-2 mapping. These revealed reversibly reduced left atrial and ventricular action poten ...
【Theranostics】Brain-to-heart cholinergic synapse-calcium signaling mediates ischemic stroke-induced atrial fibrillation
The middle cerebral artery occlusion/reperfusion model was adapted to create subacute brain ischemia in rats with normal cardiac function. Invasive electrophysiologic studies and ex vivo optical mapping wer ...
【Phytomedicine】Sophoridine manifests as a leading compound for anti-arrhythmia with multiple ion-channel blocking effects
Using electrical and optical mapping, the negative chronotropic effect of SR was determined in langendorff-perfused rat or guinea-pig hearts. The antiarrhythmic activity of SR was assessed by the ex vivo ta ...
【Communications Biology】Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates
The most significant feature that distinguishes cardiomyocytes from other cells is that they can beat autonomously, Observing their electrophysiological function changes will help to reveal the new mechanis ...
【Journal of Ethnopharmacology】Traditional Chinese Medicine YangxinDingji alleviates arrhythmias through inhibition of sodium and L-type calcium channels
To elucidate the electrophysiological mechanism of YXDJ, optical mapping was used to assess its impact on cardiac electrical and calcium disturbances in the isolated hearts. (A) The schematic diagram ...
