Electrical mapping was performed to probe the electrophysiology reconstruction of the infarcted heart after the patches’ transplantation for 4 weeks. Epicardial electrical mapping, through collecting and analyzing the electrical activity of the LV free wall, generated electrical conduction velocity (CV) maps from the non-infarcted myocardium to the infarcted myocardium.

A.The schematic diagram of electrical mapping from Langendorff-perfused hearts in different groups at week 4 post-transplantation.

B.Representative ECG traces of different groups.

C.The field potential amplitude of the remote region,border region and scar region in different groups at week 4 post-transplantation.

D.Conduction velocity of different groups calculated based on epicardial activation maps (n = 5 independent rats).

E.The QRS duration of different groups were calculated based on ECG (n = 5 independent rats).

F, G.Statistics analysis of the border/remote field potential amplitude.

Nature Communications (IF15.7)

https://doi.org/10.1038/s41467-024-48468-x2