Previous studies suggested that conductive CPs could act as a robust tool to improve the electrical integration in the infarcted hearts, which was essential for the MI repair. Here, they directly evaluated the influence of different CPs on electrical integration by measuring the electrical conduction velocities and local potential amplitudes between healthy and infarcted cardiac tissues within isolated Langendorff-perfused hearts after surgery for 28 days using an electrical mapping system.

(A) Representative epicardial activation maps were recorded by 64-channel electromapping system from the healthy myocardium to the infarcted myocardium in different groups. Ruler: red represented the first activation, blue represented the last activation; and numbers indicated activation time (ms). The conduction direction arrived from red to blue.

(B) The spontaneous potential amplitudes at the infarcted area in different groups without additional stimulation.

Bioactive Materials (IF20.3)

https://doi.org/10.1016/j.bioactmat.2024.02.012