2707, 2021

Optical Mapping: Cardiac Regeneration

By |July 27th, 2021|Categories: Blog|Comments Off on Optical Mapping: Cardiac Regeneration

by Dr Jay Lu In this mini blog, we would like to highlight one of the most exciting applications in optical mapping: Cardiac Regeneration. Due to a shortage of organ donors and the limited retention of cellular therapies, cardiac engineering has created a process to generate functional cardiac tissues. Cardiac regeneration provides an alternative to the reparation of damaged heart tissue and restores cardiac function (1,2). One of which, cardiac patches appear to hold a huge potential to repair [...]

2801, 2021

Meet the Professor: An interview with Chi Keung Lam

By |January 28th, 2021|Categories: Blog|Comments Off on Meet the Professor: An interview with Chi Keung Lam

by Dr Jay Lu In this blog post, we have a pleasure to sit down to chat with Professor Chi Keung Lam about his journey in cardiovascular research and the goal of the Lam lab. Dr. Lam is an Assistant Professor in the Department of Biological Science at University of Delaware. The Lam lab uses multiple platforms from human induced pluripotent stem cell (iPSC) to in vivo rodent models to identify disease mechanisms in both cardiac physiology and pathophysiology, and [...]

2611, 2020

The Physiological Significance of Optical Mapping

By |November 26th, 2020|Categories: Blog|Comments Off on The Physiological Significance of Optical Mapping

by Dr Jay Lu In our earlier post, we touched base on the applications and benefits of cardiac optical mapping, but the physiological significance still leaves room to be explored. As we discussed, the optical mapping technique was developed to help us determine the electrical properties of multicellular cardiac preparations, ranging from iPSC-cardiomyocyte to intact heart ex vivo and in vivo. The secret sauce of optical mapping is to grasp high-speed fluorescence-based imaging with various probes for transmembrane potential (Vm), intracellular [...]

3107, 2020

How Cardiac Mapping Can Enhance CiPA?

By |July 31st, 2020|Categories: Blog|Comments Off on How Cardiac Mapping Can Enhance CiPA?

by Dr Jay Lu What is CiPA? The Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative is created collectively by an international multidisciplinary team of regulatory, industry, and academic scientists to develop a new paradigm for the cardiac safety evaluation of new drugs that provides a more accurate and comprehensive mechanistic-based assessment of proarrhythmic potential. It is designed to focus on assessing the proarrhythmic risk of drugs, building on the emergence of new technologies, and expanding understanding of torsadogenic mechanisms [...]

806, 2020

An Update on COVID-19 Potential Treatment with HCQ

By |June 8th, 2020|Categories: Blog|Comments Off on An Update on COVID-19 Potential Treatment with HCQ

by Dr Jay Lu Hydroxychloroquine (HCQ) has been touted as a promising and effective treatment for patients with the COVID-19 infection. The drug is often recommended to be used in conjunction with azithromycin, an antibiotic. In this article, we will have a closer look at recent studies on hydroxychloroquine, which may shed light on why the W.H.O. has halted clinical trials of HCQ for COVID-19. While there is some reported beneficial effect with hydroxychloroquine (HCQ) and azithromycin (AZM) for [...]

1704, 2020

Hydroxychloroquine, to Take or Not to Take?

By |April 17th, 2020|Categories: Blog|Comments Off on Hydroxychloroquine, to Take or Not to Take?

-The risk of COVID-19 potential treatment By Dr Jay Lu Coronavirus, COVID-19, or simply as the infamous pandemic that plagued the world since late 2019, we have all heard about the virus spreading across the globe. But how many of us understand the real statistics and risks behind COVID 19? In this article, we aim to shed some light on the virus, potential treatments, and the possible risks involved The Deadly Path Of COVID-19 Since its unforeseen [...]

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