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Delving into the Potential of Electrical and Optical Mapping Techniques in iPSC-CM Research(Video)
by Dr Jay Lu In our previous blog post, we discussed “Why iPSC Technology is Vital to Cardiac Research”. In this post, we present a comprehensive video on how you can employ both electrical mapping with microelectrode arrays (MEAs) and optical mapping technologies for iPSC-CM research and acquire a wealth of ...
Harnessing the Power of Electrical and Optical Mapping Systems in Cardiac Repair Studies
by Dr Jay Lu Cardiac tissue engineering has reached new heights with the development of an intrapericardial injectable hydrogel patch that enables mechanical-electrical coupling with infarcted myocardium. This innovative approach, pioneered by Yu et al., has shown remarkable efficacy in preventing ventricular fibrosis and remodeling, promoting neovascularization, and restoring electrical ...
Electrical Mapping – Advancing iPSC-CM Research with Microelectrode Array
by Dr Jay Lu In this post, we are presenting a comprehensive, step-by-step tutorial video on how to measure electrical activity in iPSC-CM. Please also note that Electrical Mapping System can work on various cardiac tissues, ranging from the whole heart to iPS-CM, to pinpoint the exact areas of diseased ...
The Significance of Conduction Dispersion in Cardiac Electrophysiology
by Dr Jay Lu In this blog post, we’d like to discuss conduction dispersion, a critical parameter in cardiac electrophysiology. Conduction dispersion refers variations in the time it takes for an action potential to travel through the heart muscle. More specifically, it is a measure of the inhomogeneity of conduction ...
Proarrhythmia and Action Potential Triangulation: A Quick Overview
by Dr Jay Lu In this blog, we will explore the concept of proarrhythmia, a serious adverse effect of certain medications that can disrupt the normal electrical activity of the heart and lead to life-threatening arrhythmias, such as early afterdepolarizations (EADs) and Torsade de Pointes (TdP). The normal electrical activity ...
The importance of Effective Refractory Period in Cardiac Electrophysiology
by Dr Jay Lu In this post, we’d like to discuss the effective refractory period (ERP), which is one of the most important indices in cardiac electrophysiology. ERP simply means during cardiac action potential phase 0, 1, 2, and part of phase 3, the cells is refractory to the initiation ...