Drug Evaluation and Screening
MappingLab addresses cardiovascular R&D bottlenecks for both Western and TCM drugs, providing integrated multi scale platforms (ion channel to in vivo) for high throughput screening, safety evaluation, and mechanistic elucidation—extendable to neuroscience, oncology, and metabolism, driving data driven drug discovery.
Application of PhysioX Mapping System in Drug Evaluation and Screening
PhysioX Mapping System This system loads calcium (or other ion) fluorescent dyes into test cells, where the dyes enter the cytoplasm, bind to intracellular calcium ions, and alter their fluorescence intensity wit ...
Application of Optical Mapping System in Drug Evaluation and Screening
Schematic Diagram of the Optical Path Optical Path Optical Mapping System and Accessories Dye loading of the heart Simultaneous Acquisition of AP and Ca Transient From Tens of Thousands of Channels Re ...
Application of Electrical Mapping System in Drug Evaluation and Screening
Electrical Mapping System Using multi-site recording electrodes in direct contact with excitable tissues or cells, electrical signals are simultaneously acquired from multiple locations. Dedicated software then proce ...
【Theranostics】Brain-to-heart cholinergic synapse-calcium signaling mediates ischemic stroke-induced atrial fibrillation
The middle cerebral artery occlusion/reperfusion model was adapted to create subacute brain ischemia in rats with normal cardiac function. Invasive electrophysiologic studies and ex vivo optical mapping wer ...
【The Journal of biological chemistry】Exenatide reduces atrial fibrillation susceptibility by inhibiting hKv1.5 and hNav1.5 channels
The effects of exenatide on cardiac electrophysiology and atrial fibrillation (AF) activity were investigated in isolated rat hearts using an electrical mapping system. Its antiarrhythmic potential was subs ...
【Phytomedicine】Sophoridine manifests as a leading compound for anti-arrhythmia with multiple ion-channel blocking effects
Using electrical and optical mapping, the negative chronotropic effect of SR was determined in langendorff-perfused rat or guinea-pig hearts. The antiarrhythmic activity of SR was assessed by the ex vivo ta ...
【Journal of Ethnopharmacology】Traditional Chinese Medicine YangxinDingji alleviates arrhythmias through inhibition of sodium and L-type calcium channels
To elucidate the electrophysiological mechanism of YXDJ, optical mapping was used to assess its impact on cardiac electrical and calcium disturbances in the isolated hearts. (A) The schematic diagram ...
【Communications Biology】Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates
The most significant feature that distinguishes cardiomyocytes from other cells is that they can beat autonomously, Observing their electrophysiological function changes will help to reveal the new mechanis ...
【Cardiovascular Research】Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node
Electrophysiological characterization of GLP-1 effects in vivo and in isolated perfused hearts localized electrical modulation to the atria and conduction system. In isolated sinus nodes, GLP-1 administrati ...
【Biomedicine & Pharmacotherapy】Sanwei sandalwood decoction ameliorates acute ischemiareperfusion injury in rats by modulating myocyte electrophysiological characteristics
The Sanwei Tanxiang decoction powder slowed the heart rate and conduction velocity in normal rats; significantly prolonged ventricular repolarization time and effective refractory period, and mildly extende ...
【ACS Pharmacol Transl Sci】Electrophysiological and Proarrhythmic Effects of Hydroxychloroquine Challenge in Guinea-Pig Hearts
Effects of μM-HCQ were studied in isolated perfused guinea-pig hearts by multielectrode, optical RH237 voltage, and Rhod-2 mapping. These revealed reversibly reduced left atrial and ventricular action poten ...
