Myocardial Infarction
Myocardial infarction (MI) causes ischemia, necrosis, and often fatal arrhythmias (e.g., AF/VF), as well as post-infarct fibrosis with conduction abnormalities. Conventional research tools lack the resolution to capture these dynamic electrophysiological changes. Our integrated platform combines high-resolution optical and multi-channel electrical mapping to synchronously acquire voltage and Ca²⁺ signals, quantifying key parameters (APD90, calcium transient amplitude, conduction velocity) to clearly characterize healthy, border-zone, and infarcted tissues. This supports mechanistic studies, drug screening, and preclinical evaluation, accelerating translational research and therapy development for MI.
Application of Optical Mapping System in Myocardial Infarction
Schematic Diagram of the Optical Path Optical Path Optical Mapping System and Accessories Dye loading of the heart Simultaneous Acquisition of AP and Ca Transient From Tens of Thousands of Channels Optica ...
【Research (Washington, D.C.)】Cardiac-Adaptive Conductive Hydrogel Patch Enabling Construction of Mechanical–Electrical Anisotropic Microenvironment for Heart Repair
Heart cells are prone to apoptosis caused by MI-induced hypoxia, and angiogenesis can reduce MI-caused damage by mitigating hypoxia. Angiogenesis plays an essential role in maintaining cardiac vascularizati ...
【Nature Communications】Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy
To explain the electrical coupling treatment of CAHP, cardiac electrophysiology was visualized to analyze the compensatory electrical conduction effects of CAHP in the infarct region. The isolated perfused ...
【Nature Biomedical Engineering】Injectable and conductive cardiac patches repair infarcted myocardium in rats and minipigs
The electrical mapping was performed on the isolated Langendorff-perfused rat hearts after the patches were implanted onto the infarcted hearts for 4 weeks. These results provide evidence that the conductiv ...
【Heart Rhythm】TRPV4 inhibition suppresses myocardial ischemia-reperfusion arrhythmia of mice by alleviating calcium handling abnormalities
Cardiac alternans were induced by increasing the pacing frequency. It was found that action potential duration (APD) alternans increased 10 minutes after reperfusion, while pretreatment with GSK219 or TRPV4 ...
【Exploration】Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling
Using optical mapping to analyze action potentials in different regions of the heart (normal zone (N), peri-infarct zone (P), and infarct zone (I) of the myocardial infarction heart), it was found that comp ...
【Composites Part B: Engineering】Inhibition of neuron and cardiac remodeling by microenvironment-responsive injectable hydrogels with sympatho-immune regulation properties for myocardial infarction therapy
Confirmed by electrical mapping technology, the CNP/Sema3A-loaded hydrogel can significantly increase the electrical impulse conduction velocity of infarcted myocardial tissue and reduce conduction dispersi ...
【Clinical and Translational Medicine】Enhanced human adipose-derived stem cells with VEGFA and bFGF mRNA promote stable vascular regeneration and improve cardiac function following myocardial infarction
The electrical mapping system was used to detect changes in left ventricular electrical conduction at 15 minutes and 4 weeks after myocardial infarction (MI). Conduction time (CT), conduction velocity (CV), ...
【Biomaterials】A functional cardiac patch with “gas and ion” dual-effect intervention for reconstructing blood microcirculation in myocardial infarction repair
Synchronized cardiac contractions rely on the conduction of electrophysiological signals. The electrical signals in the infarcted area are blocked upon aggregation of the scar collagen. To further explore t ...
【Bioactive Materials】A cigarette filter-derived biomimetic cardiac niche for myocardial infarction repair
Previous studies suggested that conductive CPs could act as a robust tool to improve the electrical integration in the infarcted hearts, which was essential for the MI repair. Here, they directly evaluated ...
【Advanced Materials】Pericardial Delivery of SDF-1α Puerarin Hydrogel Promotes Heart Repair and Electrical Coupling
The contraction and relaxation of cardiomyocytes rely on periodic action potentials, a process closely associated with calcium. Impaired myocardial function is partly attributed to alterations in excitation ...
【Advanced Functional Materials】A Vascularized Conductive Elastic Patch for the Repair of Infarcted Myocardium through Functional Vascular Anastomoses and Electrical Integration
Previous studies suggested that conductive ECPs display improved electrical integration with infarcted hearts by detecting CX-43 protein expression in the infarcted region. In this article they measured the ...
【AcsNano】Injectable Hydrogels Encapsulating Dual-Functional Au@Pt Core–Shell Nanoparticles Regulate Infarcted Microenvironments and Enhance the Therapeutic Efficacy of Stem Cells through Antioxidant and Electrical Integration
The electrical propagation of MI was obtained in different groups by electrical mapping and velocities of electric conduction was calculated. (c) Representative epicardial activation maps located on ...
【AcsNano】An Intrapericardial Injectable Hydrogel Patch for Mechanical–Electrical Coupling with Infarcted Myocardium
Synergistic Recovery of Cardiac Electrophysiological and Diastolic-Systolic Functions.Nonconductive fibrotic tissue was insensitive to electrical stimulation and propagation, leading to ventricular electrop ...
