Cardiac Tissue Engineering
In cardiac tissue engineering, restoring electrical function is as vital as structural repair. Electrophysiological mapping has become the gold standard for evaluating how engineered constructs integrate with host myocardium. Using high-density multielectrode arrays, MappingLab systems enable precise quantification of conduction velocity, activation patterns, and field potential amplitudes in Langendorff-perfused heart models. These parameters directly assess whether conductive patches, hydrogels, or cell therapies improve electrical integration between healthy and infarcted regions—moving beyond traditional histological markers. As demonstrated in numerous high-impact publications, mapping technology provides the critical functional evidence reviewers demand, helping researchers answer the core question: "To what extent does your strategy truly restore cardiac conduction?"
Application of Optical Mapping System in Tissue Engineering Research
Schematic Diagram of the Optical Path Optical Path Optical Mapping System and Accessories Dye loading of the heart Simultaneous Acquisition of AP and Ca Transient From Tens of Thousands of Channels Optica ...
Application of Electrical Mapping System in Tissue Engineering Research
Electrical Mapping System Using multi-site recording electrodes in direct contact with excitable tissues or cells, electrical signals are simultaneously acquired from multiple locations. Dedicated software then proce ...
【Research (Wash D C)】Cardiac-Adaptive Conductive Hydrogel Patch Enabling Construction of Mechanical–Electrical Anisotropic Microenvironment for Heart Repair
Heart cells are prone to apoptosis caused by MI-induced hypoxia, and angiogenesis can reduce MI-caused damage by mitigating hypoxia. Angiogenesis plays an essential role in maintaining cardiac vascularizati ...
【Regenerative Biomaterials】Enhanced prevention on postoperative atrial fibrillation by using anti-inflammatory biodegradable drug patch
Ex vivo optical mapping experiments included: recording atrial arrhythmia inducibility (AF and tachycardia) via burst-pacing; detecting atrial conduction velocity (CV) at S1-S1 intervals of 240–160 ms; desc ...
【Nature Communications】Engineered model of heart tissue repair for exploring fibrotic processes and therapeutic interventions
MI frequently precipitates arrhythmias by impairing CM function and inducing fibrosis, which impedes cardiac electrical signal propagation. Utilizing cardiac optical mapping with calcium-sensitive dye, they ...
【Nature Communications】E-cardiac patch to sense and repair infarcted myocardium
Electrical mapping was performed to probe the electrophysiology reconstruction of the infarcted heart after the patches’ transplantation for 4 weeks. Epicardial electrical mapping, through collecting and an ...
【Nature Communications】Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy
To explain the electrical coupling treatment of CAHP, cardiac electrophysiology was visualized to analyze the compensatory electrical conduction effects of CAHP in the infarct region. The isolated perfused ...
【Nature Biomedical Engineering】Injectable and conductive cardiac patches repair infarcted myocardium in rats and minipigs
The electrical mapping was performed on the isolated Langendorff-perfused rat hearts after the patches were implanted onto the infarcted hearts for 4 weeks. These results provide evidence that the conductiv ...
【Cell Reports Medicine】A functional cardiac patch promotes cardiac repair by modulating the CCR2- cardiac-resident macrophage niche and their cell crosstalk
The in vitro experiments demonstrated that as the scaffold, pHH CCP improved the intracellular CX43 expression of CMs, while functional PSL/pIL4@pHH CCP further up-regulated the expression of CX43 between C ...
【Biomaterials】A functional cardiac patch with “gas and ion” dual-effect intervention for reconstructing blood microcirculation in myocardial infarction repair
Synchronized cardiac contractions rely on the conduction of electrophysiological signals. The electrical signals in the infarcted area are blocked upon aggregation of the scar collagen. To further explore t ...
【Bioactive Materials】A cigarette filter-derived biomimetic cardiac niche for myocardial infarction repair
Previous studies suggested that conductive CPs could act as a robust tool to improve the electrical integration in the infarcted hearts, which was essential for the MI repair. Here, they directly evaluated ...
【Advanced Materials】Pericardial Delivery of SDF-1α Puerarin Hydrogel Promotes Heart Repair and Electrical Coupling
Optical mapping was employed to assess myocardial repolarization refractory periods, determine APD90 prolongation post-MI, and analyze action potential (AP) disparities between infarcted and normal cardiac ...
【Advanced Functional Materials】A Vascularized Conductive Elastic Patch for the Repair of Infarcted Myocardium through Functional Vascular Anastomoses and Electrical Integration
Previous studies suggested that conductive ECPs display improved electrical integration with infarcted hearts by detecting CX-43 protein expression in the infarcted region. In this article they measured the ...
【Advanced Functional Materials】A Strongly Robust Chitosan-Based Programmed Control Functional Hydrogel Improved Mitochondrial Function and Pro-Vascularization for Adaptive Repair of Myocardial Infarction
MI resulted in a significant delay in the conduction of electrical signals, whereas hydrogel treatment accelerated electrical signal conduction in the infarcted heart. The electrical mapping system was used ...
【AcsNano】Injectable Hydrogels Encapsulating Dual-Functional Au@Pt Core–Shell Nanoparticles Regulate Infarcted Microenvironments and Enhance the Therapeutic Efficacy of Stem Cells through Antioxidant and Electrical Integration
The electrical propagation of MI was obtained in different groups by electrical mapping and velocities of electric conduction was calculated. (c) Representative epicardial activation maps located on the bor ...
【AcsNano】An Intrapericardial Injectable Hydrogel Patch for Mechanical–Electrical Coupling with Infarcted Myocardium
Synergistic Recovery of Cardiac Electrophysiological and Diastolic-Systolic Functions.Nonconductive fibrotic tissue was insensitive to electrical stimulation and propagation, leading to ventricular electrop ...
